These are just things I learned running it and they worked for me but might not be the case for everybody
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Focus on just the core book. WoD has always suffered from bloat and an early game I ran got out of hand pretty quick bc I let PCs pick from anything
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Start small. 5e I think does a balance of horror great, but don't worry about shit going on in the far corners of the world with millennia-old vampires; let your PCs carve their niche out first
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Lorebooks at your own risk. I didn't like them but again, IDGAF about the metaplot
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Don't forget hunger is always there and should affect rolls but also you should always be challenging that hunger. I'm not a combative dm/st/gm whatever but like ... I think that's the whole point. Kindred existence is just a constant war of controlling the Beast.
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Ask lots of questions and use those answers against the players especially during character creation and extra especially with Advantages and Flaws
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Watch having thin-bloods in with your genned kindred. I felt like there was a huge power gap, or at least make players aware it might get weird
Idk the rules went fine but I'm used to WoD dice pool weirdness. I never house-ruled any of the 5e rules myself other than the mixed-gen coterie thing