this post was submitted on 10 Mar 2026
25 points (96.3% liked)

Transfem

5335 readers
30 users here now

A community for transfeminine people and experiences.

This is a supportive community for all transfeminine or questioning people. Anyone is welcome to participate in this community but disrupting the safety of this space for trans feminine people is unacceptable and will result in moderator action.

Debate surrounding transgender rights or acceptance will result in an immediate ban.

This community is supportive of DIY HRT. Unsolicited medical advice or caution being given to people on DIY will result in moderator action.

Posters may express that they are looking for responses and support from groups with certain experiences (eg. trans people, trans people with supportive parents, trans parents.). Please respect those requests and be mindful that your experience may differ from others here.

Some helpful links:

Support Hotlines:

founded 2 years ago
MODERATORS
 

I unfortunately live in a not very trans friendly state in the US (more like trans hostile tbh) so I've been doing my HRT pretty much solo/without seeing doctors. Been doing mono estradiol enanthate for about a year now following the manufacturer's recommendations (0.15 mL every 7 days) and wanted to try getting on prog but i'm not sure what dosage i should be at. any recommendations?

you are viewing a single comment's thread
view the rest of the comments
[–] dandelion@lemmy.blahaj.zone 9 points 2 days ago* (last edited 2 days ago)

100 mg, rectally, once per night - taking it orally results in the dose almost entirely being absorbed by the liver and does not sufficiently raise blood progesterone levels, so rectal administration ensures you actually are getting the dose. Unfortunately it's the only realistic alternative route of administration to oral, currently.

Also, you want to take micronized bioidentical progesterone (the ones that are in oil and come in gel capsules intended to be taken orally, they are safe to insert rectally). You don't want to take medroxyprogesterone acetate (MPA) which is often called "progesterone" and which some trans women have taken (esp. historically). MPA has some negative long-term health risks associated with it..