this post was submitted on 10 Mar 2026
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I unfortunately live in a not very trans friendly state in the US (more like trans hostile tbh) so I've been doing my HRT pretty much solo/without seeing doctors. Been doing mono estradiol enanthate for about a year now following the manufacturer's recommendations (0.15 mL every 7 days) and wanted to try getting on prog but i'm not sure what dosage i should be at. any recommendations?

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[–] WillStealYourUsername@piefed.blahaj.zone 9 points 2 days ago* (last edited 2 days ago)

Orally I typically see people take 100mg to 200mg. I've also seen 300mg, but that's less common. Advice on transdermal prog is purely a DIY thing and what I've heard about dosing there is 6mg-12mg.

Mostly people take these doses once everyday, usually right before they go to bed. Some people "cycle" progesterone which means they have breaks. Some people might do two weeks of prog and then then two weeks of no prog, and I've heard cis women who take five days of prog and then two days of no prog.

Prog does not have any fancy guidelines for us to follow so a lot of the advice around it is anecdotal.

Edit: Oh yeah I should mention I do transdermal prog, 12 mg once a day before going to bed. With transdermal be sure to apply to the breasts, unlike with estradiol which should never be applied to the breasts.

Edit edit: Also, it's generally recommended to take it rectally rather than orally. Most oral prog pills can be taken rectally.