this post was submitted on 25 Feb 2026
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I’m finally getting my hormones! I’m gonna do injections, and my doctor said she’s comfortable prescribing me oral progesterone as well if I want it. And it’s a female hormone, so why shouldn’t I have it, right? I know it’s supposed to help with breast development, and maybe libido, but I haven’t done as much reading about progesterone as I have estrogen. Should I start it at the same time I start estrogen? Is it even worth taking? Would love to hear others’ thoughts and experiences

EDIT: Seems like the rough consensus is to wait around a year, so I think that’s what I’ll plan on doing. Thanks y’all!

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[–] dandelion@lemmy.blahaj.zone 1 points 1 week ago

it's hard to follow a monthly basis when my actual hormone changes are on a weekly cycle, it's based on the pharmacokinetics of estradiol valerate, when a half life is around 3.5 days and I inject once a week, I have a cycle then that has highs and lows over a weekly period (not a monthly period).

So, the week is like a compressed month - I have highs and lows and in a monthly cycle, progesterone levels rise when estradiol levels rise, so I just roughly do something similar by taking prog when my E levels are gaining and peaking, and then stopping as my E levels drop and then bottom out before my next injection.

regarding mood, I didn't really solve the mood issues until I had an orchi - my mental health got much better after that. Before then I was doing monotherapy and I struggled to sufficiently block T production even with very high levels of E (like >500 pg / mL at trough, which is really too high for long-term levels).