this post was submitted on 27 Nov 2025
39 points (100.0% liked)

Transfem

4892 readers
50 users here now

A community for transfeminine people and experiences.

This is a supportive community for all transfeminine or questioning people. Anyone is welcome to participate in this community but disrupting the safety of this space for trans feminine people is unacceptable and will result in moderator action.

Debate surrounding transgender rights or acceptance will result in an immediate ban.

This community is supportive of DIY HRT. Unsolicited medical advice or caution being given to people on DIY will result in moderator action.

Posters may express that they are looking for responses and support from groups with certain experiences (eg. trans people, trans people with supportive parents, trans parents.). Please respect those requests and be mindful that your experience may differ from others here.

Some helpful links:

Support Hotlines:

founded 2 years ago
MODERATORS
 

I’m interested in that feeling of relief some of us get after taking our estradiol dose. I experience it as intense relief that washes over me and bathes me in joy. My color perception dramatically improves at the same time, it’s a very sudden shift.

I seem to only experience it when my blood levels are too low and the new dose enters the blood. With Divigel it’s after 30 minutes have passed, in my case, but only if me levels are low.

Some questions I have:

  • If I don’t feel the relief, am I overdosed?
  • If I do feel the relief, am I underdosed?
  • Why do I and some feel the relief, while others have never felt it?

I don’t expect anyone to know the definitive answers, but maybe you can share your experience? I’m really interested in learning what this is all about.

you are viewing a single comment's thread
view the rest of the comments
[–] lwhjp@piefed.blahaj.zone 12 points 1 week ago (3 children)

This is a bit of a cop-out answer, but the effects of HRT vary hugely based on the person. The "relief" you are feeling might be placebo, might be due to biochemical dysphoria, or a bit of both.

When I was on injections, I definitely felt a bit crappy at the end of the week, and a lot better about 30 minutes after my dose.

When I was getting my dose for patches worked out, I felt what I can only describe as "testosterone anxiety", which persisted as I slowly bumped up my dose over a couple of weeks and eventually went away when I got up to three patches. (Now I'm on spiro and back down to two, and things are fine). This was a different feeling to injections wearing off.

Now the only thing I notice is that I get four days of being really tired and bitchy pretty consistently every 25 days or so. I'm not going to speculate what that is, but since I'm on a very stable dose of two patches every two days, I don't think it's due to dosage.

[–] femtek@lemmy.blahaj.zone 2 points 6 days ago (1 children)

What's your dose? I'm using patches and on one patch, replaced twice a week.

[–] lwhjp@piefed.blahaj.zone 1 points 5 days ago

I'm on 2 x 0.72 mg patches every two days, plus 50 mg spiro and 100 mg prog every day. That gets me to 268 pg/mL E2 and 58 ng/dL testosterone, last blood test. I'd like to switch to a different anti-androgen though; I'm getting pretty fed up with the effects of spiro.

load more comments (1 replies)